Il12b Rat Recombinant Protein

CAT#: TP724812

Rat Interleukin-12/IL-12(C-His)

Specifications

Product Data

• Species: Rat
• Protein Source: Human 293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Met23-Ser335(p40)&Arg23-Ser215(p35)
• Tag: C-6His
• Buffer: Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
• Note: Recombinant Rat Interleukin-12 is produced by our Mammalian expression system and the target gene encoding Met23-Ser335(p40)&Arg23-Ser215(p35) is expressed with a 6His tag at the C-terminus.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 64546
• Summary: Interleukin-12 (IL-12) is a heterodimeric pleiotropic cytokine that consists of IL12A (p35) and IL12B (p40) subunits. IL‑12 is expressed by macrophages and B lymphocytes and act as a growth factor for activated T and NK cells, help enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Studies have shown that IL‑12 is a key mediator of cellular-immunity and induces the differentiation of Th1 cells from precursor T helper cells. Based on its activities, it has been predicted that IL‑12 may have therapeutic potential as a vaccine adjuvant that promotes cellular-immunity and as an anti-tumor and anti-viral agent.