CD299 (CLEC4M) Human Recombinant Protein
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Specifications
Product Data | |
Species | Human |
Protein Source | Human |
Expression cDNA Clone or AA Sequence |
Ser78-Glu399
|
Tag | C-His |
Buffer | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
Note | Recombinant DC-SIGNR/CD299 (C-His) is produced by Human Cells. The target gene encoding Ser78-Glu399 is expressed with a C-His tag. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 10332 |
UniProt ID | Q9H2X3 |
Summary | CD299 is also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligermerization. Multiple human DC-SIGN/CD209 splice forms exist, generating both membrane-bound and soluble forms. DC-SIGNR is ragarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. DC-SIGNR appears to selectively recognize and bind many viral surface glycoproteins containing high mannose N-linked oligosaccharides in a calcium-dependent manner, including HIV-1 gp12, HIV-2 gp12, SIV gp12, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S, as well as the cellular adhesion protein ICAM3. DC-SIGN/CD209 is expressed on dendritic cells (DC) and inflammatory macrophages and contributes to antigen presentation. |
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