Cynomolgus Recombinant Protein

CAT#: TP724749

Recombinant Cynomolgus IL-23R (C-hFc)

Specifications

Product Data

• Species: Cynomolgus
• Protein Source: Human
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Met1-Asp353
• Tag: C-Human Fc
• Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
• Note: Recombinant Cynomolgus IL-23R (C-hFc) is produced by Human Cells. The target gene encoding Met1-Asp353 is expressed with a C-hFc tag.
• Stability: 12 months from date of despatch

Reference Data

• Summary: Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.