HHLA2 Human Recombinant Protein

CAT#: TP724680

Recombinant Human B7-H7 (C-mFc)

Specifications

Product Data

• Species: Human
• Protein Source: Human
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Ile23-Asn344
• Tag: C-Mouse Fc
• Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
• Note: Recombinant Human B7-H7 (C-mFc) is produced by Human Cells. The target gene encoding Ile23-Asn344 is expressed with a C-mFc tag.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 11148
• UniProt ID: Q9UM44
• Summary: B7-H7 (HHLA2) is a newly identified B7 family member that regulates human T-cell functions. B7-H7 was previously known as human endogenous retrovirus-H long terminal repeat associating 2 (HHLA2) with unidentified function. Recently, B7-H7 has been identified as a specific ligand for human CD28H. The B7-H7-CD28H pathway strongly promoted CD4+ T-cell proliferation and cytokine production via an AKT-dependent signaling cascade in the presence of TCR signaling, suggesting B7-H7 comprises a new co-stimulatory pathway. The first IgV domain of B7-H7, which presumably binds to a putative receptor, shows the highest homology to other B7 family members.