DR5 (TNFRSF10B) Human Recombinant Protein

CAT#: TP724002

Human TNFRSF10B Protein, mFc Tag

Product Images

Figure 1. Human TNFRSF10B Protein, mFc Tag on SDS-PAGE under reducing condition.

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  Figure 2. ELISA plate pre-coated by 2 µg/ml (100 µl/well) Human TNFRSF10B, mFc tagged protein (TP724002) can bind Anti-TNFRSF10B Neutralizing antibody (BME100032) in a linear range of 3.2-80 ng/ml.

Specifications

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  TNFRSF10B （Ile56-Glu186）+mFc（Pro99-Lys330）
• Tag: C-Mouse Fc
• Predicted MW: 40.5 kDa
• Purity: > 95%
• Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose is added as protectants before lyophilization
• Reconstitution: Reconstitute with deionized water
• Preparation: Affinity purification
• Storage: Store the lyophilized protein at -20°C.
  After reconstitution, store the protein at -80°C for 12 months.
  Avoid repeated freezing and thawing.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 8795
• UniProt ID: O14763
• Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.