CD137 (TNFRSF9) Human Recombinant Protein

CAT#: TP723934

Human 4-1BB Protein, mFc-His Tag

Product Images

Figure 1. Human 4-1BB Protein, mFc-His Tag on SDS-PAGE under reducing condition.

• 

  Figure 2. HEK293 cell line transfected with irrelevant protein (B) and human 4-1BB Ligand (A) were surface stained with Human 4-1BB, mFc-His tagged protein (TP723934) 1µg/ml followed by Alexa 488-conjugated anti-mouse IgG secondary antibody.

Specifications

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  41BB（Leu24-Gln186）+mFc（Pro99-Lys330）+6×His
• Tag: C-Mouse Fc and 6×His
• Predicted MW: 54-60 kDa
• Purity: > 95%
• Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose is added as protectants before lyophilization
• Reconstitution: Reconstitute with deionized water
• Preparation: Affinity purification
• Applications: Flow Cyt
• Storage: Store the lyophilized protein at -20°C.
  After reconstitution, store the protein at -80°C for 12 months.
  Avoid repeated freezing and thawing.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 3604
• UniProt ID: Q07011
• Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.