EPO (NM_000799) Human Recombinant Protein

CAT#: TP723837

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Purified recombinant protein of Human erythropoietin (EPO)



  View other "EPO" proteins (3)

USD 373.00


Availability*
2 Weeks

Size
    • 10 ug


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Specifications

Product Data
Species Human
Expression Host CHO
Expression cDNA Clone or AA Sequence
Human EPO, the region of Ala28-Arg192, from gene Accession# AAI43226.1
Tag Tag Free
Predicted MW 18 kDa
Concentration lot specific
Purity >98%, as determined by Coomassie stained SDS-PAGE.
Buffer 1 x PBS
Bioactivity The ED50 is 0.2 - 1 ng/ml, corresponding to a specific activity of 1 - 5 x 10^6 units/mg, determined by the dose dependent stimulation of TF-1 cells proliferation.
Endotoxin Less than 0.01 ng per µg protein as determined by the LAL method
Storage Store at -80°C.
Stability Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Reference Data
RefSeq NP_000790
Locus ID 2056
UniProt ID P01588, G9JKG7
Cytogenetics 7q22.1
Refseq Size 1340
Refseq ORF 579
Synonyms DBAL; ECYT5; EP; MVCD2
Summary This gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies. [provided by RefSeq, Aug 2017]
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway

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Other Versions

Frequently bought together (1)
EPO rabbit polyclonal antibody
    • 25 ul

USD 800.00

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