EPO (NM_000799) Human Recombinant Protein

CAT#: TP762209

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Purified recombinant protein of Human erythropoietin (EPO), Ala28-End, with N-terminal His tag, expressed in E.coli, 50ug


 Product Datasheet for 'TP762209'

USD 205.00


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Size
    • 50 ug


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Product Data
Description Purified recombinant protein of Human erythropoietin (EPO), Ala28-End, with N-terminal His tag, expressed in E.coli, 50ug
Species Human
Expression Host E. coli
Tag N-His
Predicted MW 18.4 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50mM Tris, 8M Urea, pH8.0.
Reference Data
RefSeq NP_000790
Locus ID 2056
Refseq Size 1340
Cytogenetics 7q22.1
Refseq ORF 579
Synonyms DBAL; ECYT5; EP; MVCD2
Summary This gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies. [provided by RefSeq, Aug 2017]
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway

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