CFHL1 (CFHR1) (NM_002113) Human Recombinant Protein
CAT#: TP720693L
Purified recombinant protein of Human complement factor H-related 1 (CFHR1)
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Specifications
Product Data | |
Species | Human |
Expression Host | HEK293 |
Expression cDNA Clone or AA Sequence |
Glu19-Arg330
|
Tag | C-6His |
Predicted MW | 36.78 kDa |
Concentration | lot specific |
Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | Provided lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl |
Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg) |
Reconstitution | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. Dissolve the lyophilized protein in ddH2O. It is not recommended to reconstitute a concentration less than 100 µg/ml. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Storage | Store at -80°C. |
Stability | Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
Reference Data | |
RefSeq | NP_002104 |
Locus ID | 3078 |
UniProt ID | Q03591 |
Cytogenetics | 1q31.3 |
Refseq Size | 1312 |
Refseq ORF | 990 |
Synonyms | CFHL; CFHL1; CFHL1P; CFHR1P; FHR-1; FHR1; H36; H36-1; H36-2; HFL1; HFL2 |
Summary | This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009] |
Protein Families | Secreted Protein |
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