Desmocollin 2 (DSC2) (NM_004949) Human Recombinant Protein

CAT#: TP322207

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Purified recombinant protein of Homo sapiens desmocollin 2 (DSC2), transcript variant Dsc2b


 Product Datasheet for 'TP322207'

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USD 748.00


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    • 20 ug


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Specifications

Product Data
Description Purified recombinant protein of Homo sapiens desmocollin 2 (DSC2), transcript variant Dsc2b
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 90.8 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_004940
Locus ID 1824
Refseq Size 5186
Cytogenetics 18q12.1
Refseq ORF 2541
Synonyms ARVD11; CDHF2; DG2; DGII/III; DSC3
Summary This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Protein Families Transmembrane
Protein Pathways Arrhythmogenic right ventricular cardiomyopathy (ARVC)

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