Desmocollin 2 (DSC2) Rabbit Polyclonal Antibody
Rabbit Polyclonal Anti-DSC2 Antibody
Product Datasheet for 'TA351135'
|Recommend Dilution||ELISA: 2000-5000, IHC: 50-200|
|Immunogen||Synthetic peptide of human DSC2|
|Formulation||pH7.4 PBS, 0.05% NaN3, 40% Glyceroln|
|Purification||Antigen affinity purification|
|Gene Name||desmocollin 2|
|Background||The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11.|
|Synonyms||ARVD11; CDHF2; DG2; DGII/III; DSC3|
|Protein Pathways||Arrhythmogenic right ventricular cardiomyopathy (ARVC)|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.