PLEKHM2 (NM_015164) Human Recombinant Protein
Recombinant protein of human pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2)
Product Datasheet for 'TP320299'
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|Description||Recombinant protein of human pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2)|
|Expression cDNA Clone or AA Sequence||Recombinant protein was produced with TrueORF clone, RC220299. Click on the TrueORF clone link to view cDNA and protein sequences.|
|Predicted MW||112.6 kDa|
|Concentration||>50 ug/mL as determined by microplate BCA method|
|Purity||> 80% as determined by SDS-PAGE and Coomassie blue staining|
|Buffer||25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. Store at –80C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.|
|Summary||This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. [provided by RefSeq, Feb 2017]|
|Protein Families||Druggable Genome|