FUBP1 (NM_003902) Human Recombinant Protein

CAT#: TP315674

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Recombinant protein of human far upstream element (FUSE) binding protein 1 (FUBP1)


 Product Datasheet for 'TP315674'

 Cited in 1 publication.

  View other "FUBP1" proteins (5)

USD 748.00


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    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human far upstream element (FUSE) binding protein 1 (FUBP1)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 67.4 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Bioactivity EMSA assay (PMID: 25662218)
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_003893
Locus ID 8880
Refseq Size 2884
Cytogenetics 1p31.1
Refseq ORF 1932
Synonyms FBP; FUBP; hDH V
Summary The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Protein Families Stem cell - Pluripotency, Transcription Factors

Citations (1)

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