Plasma Kallikrein 1B (KLKB1) (NM_000892) Human Recombinant Protein

CAT#: TP311985

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Recombinant protein of human kallikrein B, plasma (Fletcher factor) 1 (KLKB1)


 Product Datasheet for 'TP311985'

  View other "KLKB1" proteins (4)

USD 788.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human kallikrein B, plasma (Fletcher factor) 1 (KLKB1)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 41.3 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_000883
Locus ID 3818
Refseq Size 2245
Cytogenetics 4q35.2
Refseq ORF 1914
Synonyms KLK3; PKK; PKKD; PPK
Summary This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Protein Families Druggable Genome, Protease
Protein Pathways Complement and coagulation cascades

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