Cryptochrome I (CRY1) (NM_004075) Human Recombinant Protein

CAT#: TP307152

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Recombinant protein of human cryptochrome 1 (photolyase-like) (CRY1)


 Product Datasheet for 'TP307152'

  View other "CRY1" proteins (3)

USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human cryptochrome 1 (photolyase-like) (CRY1)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 66.2 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_004066
Locus ID 1407
Refseq Size 3310
Cytogenetics 12q23.3
Refseq ORF 1758
Synonyms DSPD; PHLL1
Summary This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]
Protein Families Druggable Genome
Protein Pathways Circadian rhythm - mammal

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Other Versions

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