Myelin Basic Protein (MBP) (NM_001025090) Human Recombinant Protein

CAT#: TP300710

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Recombinant protein of human myelin basic protein (MBP), transcript variant 3


 Product Datasheet for 'TP300710'

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USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human myelin basic protein (MBP), transcript variant 3
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 18.4 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_001020261
Locus ID 4155
Refseq Size 2222
Cytogenetics 18q23
Refseq ORF 513
Synonyms MGC99675
Summary The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]

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Other Versions

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