VEGF-C / Flt4-L Human Protein

CAT#: PR27170-2

VEGF-C / Flt4-L human recombinant protein, 2 µg

Specifications

Product Data

• Species: Human
• Expression Host: Sf9 insect
• Predicted MW: 18-24 kDa
• Purity: >90%
• Presentation: Purified
• Buffer: Presentation State: Purified
• Bioactivity: Biological:

  This VEGF-C is fully biocative as Measured by its ability to bind to the VEGFR-3/FLT-4 receptor in the Ba/F3-hVEGFR-3 assay. The ED₅₀ in this assay is about 4ng/ml corresponding to a Specific Activity of 250,000IU/mg.

• Protein Description: Recombinant human VEGF-C, lacking the N- and C-terminal extensions and containing only the middle VEGF homology domain, forms primarily non-covalently linked dimers. This protein is a ligand for both VEGFR-2/KDR and VEGFR-3/FLT-4. Since VEGFR-3 is strongly expressed in lymphatic endothelial cells, it has been postulated that VEGF-C is involved in the regulation of the growth and/or differentiation of lymphatic endothelium. Although recombinant human VEGF-C is also a mitogen for vascular endothelial cells, it is much less potent than VEGF-A. It is also a potent trophic factor for neural stem cells.

Reference Data

• Summary:

  VEGF-C, also known as Vascular Endothelial Growth Factor Related Protein (VRP), is a recently discovered VEGF growth factor family member that is most closely related to VEGF-D. Human VEGF-C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein. Similar to VEGF-D, VEGF-C has a VEGF homology domain spanning the middle third of the precursor molecule and long N- and C-terminal extensions. In adults, VEGF-C is highly expressed in heart, placenta, ovary and small intestine.