VEGFR-3 / Flt-4 (Fc Chimera) Human Protein
VEGFR-3 / Flt-4 (Fc Chimera) human recombinant protein, 10 µg
|Description||VEGFR-3 / Flt-4 (Fc Chimera) human recombinant protein, 10 µg|
|Predicted MW||260 kDa|
|Purity||>90% by SDS-PAGE and visualised by silver stain.|
|Buffer||Presentation State: Purified
State: Lyophilized purified protein.
Buffer System: PBS without stabilizers.
|Bioactivity||Biological: Measured by its ability to bind recombinant Rat VEGF-C in a functional solid phase binding assay.
Immobilised recombinant Human sVEGFR-3/Fc at 5 µg/ml can bind recombinant Rat VEGF-C in a linear range of 8-500 ng/ml.
|Endotoxin||< 0.1 ng per µg of sVEGFR-3/Fc|
|Reconstitution||Restore in PBS or medium to a concentration not lower than 100 µg/ml.
The lyophilised sVEGFR-3/Fc is soluble in water and most aqueous buffers.
|Preparation||Lyophilized purified protein.|
|Protein Description||Recombinant Human soluble Vascular Endothelial Growth Factor Receptor-3 (sVEGFR-3) was fused with the Fc part of human IgG1. The recombinant mature sVEGFR-3/Fc is a disulfide-linked homodimeric protein. The sVEGFR-3/Fc monomers have a mass of approximately 130 kDa. The soluble receptor protein consists of all 7 extracellular domains (Met1-Glu774).|
|Note||Centrifuge vials before opening!|
|Storage||Store lyophilized at -20°C to -70°C.
Reconstituted sVEGFR-3/Fc should be stored in working aliquots at -20°C.
Avoid repeated freeze-thaw cycles!
|Stability||Shelf life: One year from despatch.|
|Synonyms||FLT-4; FLT41; LMPH1A; LMPHM1; PCL; VEGFR-3; VEGFR3|
|Summary||This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]|
|Protein Families||Druggable Genome, Protein Kinase, Transmembrane|
|Protein Pathways||Cytokine-cytokine receptor interaction, Focal adhesion|