HLA class II DO alpha / HLA-DOA (26-217, His-tag) Human Protein

CAT#: AR51010PU-S

HLA class II DO alpha / HLA-DOA (26-217, His-tag) human protein, 0.1 mg

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  MGSSHHHHHH SSGLVPRGSH MGSTKADHMG SYGPAFYQSY GASGQFTHEF DEEQLFSVDL KKSEAVWRLP EFGDFARFDP QGGLAGIAAI KAHLDILVER SNRSRAINVP PRVTVLPKSR VELGQPNILI CIVDNIFPPV INITWLRNGQ TVTEGVAQTS FYSQPDHLFR KFHYLPFVPS AEDVYDCQVE HWGLDAPLLR HWELQVPIPP PDAME
• Tag: His-tag
• Predicted MW: 24.1 kDa
• Concentration: lot specific
• Purity: >90% by SDS - PAGE
• Presentation: Purified
• Buffer: Presentation State: Purified
  State: Liquid purified protein
  Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol
• Preparation: Liquid purified protein
• Storage: Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.

Reference Data

• RefSeq: NP_002110
• Locus ID: 3111
• UniProt ID: P06340, X5CF87, A0A1V0E3Q8, A0A1V0E3S6, A0A1V0E3R8, A0A1V0E3Q1, A0A1V0E3N6, A0A1V0E3Q3, A0A1V0E3P3, A0A1V0E3N7, A0A1V0E3S4, A0A1V0E3Q4, A0A1V0E3R4, A0A1V0E3P8, A0A1V0E3R0, A0A1V0E3R3, A0A1V0E3N1, A0A1V0E3Q7, A0A1V0E3R6, A0A1V0E3N3, A0A1V0E3P0, A0A1V0E3Q5, A0A1V0E3P1, A0A1V0E3M7, A0A1V0E3P9, A0A1V0E3P6, A0A1V0E3Q2, A0A1V0E3T1, A0A1V0E3S0, A0A1V0E3S7, A0A1V0E3Q6
• Cytogenetics: 6p21.32
• Synonyms: HLA-DNA; HLA-DZA; HLADZ
• Summary: HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]
• Protein Families: Transmembrane
• Protein Pathways: Allograft rejection, Antigen processing and presentation, Asthma, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Graft-versus-host disease, Systemic lupus erythematosus, Type I diabetes mellitus, Viral myocarditis