Insulin-like growth factor I / IGF1 (Long R3) Human Protein
Recombinant Human IGF-I LR3 is a 9.1 kDa, single, non-glycosylated polypeptide chain containing 83 amino acid residues.
|Description||Recombinant Human IGF-I LR3 is a 9.1 kDa, single, non-glycosylated polypeptide chain containing 83 amino acid residues.|
|Expression Host||E. coli|
|Expression cDNA Clone or AA Sequence||MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA|
|Predicted MW||9.1 kDa|
|Purity||> 98 % pure by SDS-PAGE and HPLC analyses|
|Bioactivity||The ED50 was determined by a cell proliferation assay using FDC-P1 cells is = 2.0 ng/ml, corresponding to a specific activity of = 5 x 105 units/mg.|
|Endotoxin||< 0.1 ng per µg (1EU/µg)|
|Reconstitution||Restore in water to a concentration of 0.1-1.0 mg/ml.
This solution can then be diluted into other aqueous buffers and stored at 2-8°C for 1 week or -20°C for future use.
|Preparation||Lyophilized (sterile filtered) purified protein without additives|
|Synonyms||IGF; IGF-I; IGFI; MGF|
|Summary||The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]|
|Protein Families||Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein|
|Protein Pathways||Dilated cardiomyopathy, Focal adhesion, Glioma, Hypertrophic cardiomyopathy (HCM), Long-term depression, Melanoma, mTOR signaling pathway, Oocyte meiosis, p53 signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer|