RAB7L1 (RAB29) (NM_001135662) Human Mass Spec Standard

CAT#: PH327093

RAB7L1 MS Standard C13 and N15-labeled recombinant protein (NP_001129134)

Product Images

Coomassie blue staining of purified RAB29 protein (Cat# TP327093). The protein was produced from HEK293T cells transfected with RAB29 cDNA clone (Cat# RC227093) using MegaTran 2.0 (Cat# TT210002).

Specifications

Product Data

• Tag: C-Myc/DDK
• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence: RC227093
• Predicted MW: 23.2 kDa
• Protein Sequence:
  Sequence Link

  >RC227093 protein sequence
  Red=Cloning site Green=Tags(s)
  
  MGSRDHLFKVLVVGDAAVGKTSLVQRYSQDSFSKHYKSTVGVDFALKVLQWSDYEIVRLQLWDIAGQERF
  TSMTRLYYRDASACVIMFDVTNATTFSNSQRWKQDLDSKLTLPNGEPVPCLLLANKCDLSPWAVSRDQID
  RFSKENGFTGWTETSVKENKNINEAMRVLIEKMMRNSTEDIMSLSTQGDYINLQTKSSSWSCC
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >0.05 µg/µL as determined by microplate BCA method
• Labeling Method: Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
• Buffer: 25 mM Tris-HCl, 100 mM glycine, pH 7.3
• Storage: Store at -80°C. Avoid repeated freeze-thaw cycles.
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.

Reference Data

• RefSeq: NP_001129134
• RefSeq Size: 3223
• RefSeq ORF: 609
• Synonyms: RAB7L; RAB7L1
• Locus ID: 8934
• UniProt ID: O14966, Q6FGU7, B2R7I9
• Cytogenetics: 1q32.1
• Summary: Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.[UniProtKB/Swiss-Prot Function]
• Protein Families: Druggable Genome