CYRIB (NM_016623) Human Mass Spec Standard

SKU
PH305660
FAM49B MS Standard C13 and N15-labeled recombinant protein (NP_057707)
  $3,360.00
3 Weeks*
Bulk/Customize
Specifications
Specifications
Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC205660
Predicted MW 36.7 kDa
Protein Sequence
Protein Sequence
>RC205660 protein sequence
Red=Cloning site Green=Tags(s)

MGNLLKVLTCTDLEQGPNFFLDFENAQPTESEKEIYNQVNVVLKDAEGILEDLQSYRGAGHEIREAIQHP
ADEKLQEKAWGAVVPLVGKLKKFYEFSQRLEAALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTL
RFDELKMTNPAIQNDFSYYRRTLSRMRINNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVS
ENKNLPIENTTDCLSTMASVCRVMLETPEYRSRFTNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKID
MKGCIKVLKDQPPNSVEGLLNALRYTTKHLNDETTSKQIKSMLQ

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_057707
RefSeq Size 3838
RefSeq ORF 972
Synonyms BM-009; CYRI; CYRI-B; FAM49B; L1
Locus ID 51571
UniProt ID Q9NUQ9
Cytogenetics 8q24.21
Summary Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling (PubMed:31285585, PubMed:30250061). Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization (PubMed:30250061). Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry (PubMed:31285585). Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes (By similarity). Involved in the regulation of mitochondrial dynamics and oxidative stress (PubMed:29059164).UniProtKB/Swiss-Prot Function
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Other "CYRIB" proteins (3)
SKU Description Size Price
LC413876 Lyophilized FAM49B HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY413876 Transient overexpression lysate of family with sequence similarity 49, member B (FAM49B) (as WB positive control) 100 ug
$436.00
TP305660 Recombinant protein of human family with sequence similarity 49, member B (FAM49B), 20 µg 20 ug
$867.00

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