ATR (NM_001184) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC224837L1V

Lenti ORF particles, ATR (Myc-DDK tagged) - Human ataxia telangiectasia and Rad3 related (ATR), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: ATR
• Synonyms: FCTCS; FRP1; MEC1; SCKL; SCKL1
• Mammalian Cell Selection: None
• Vector: pLenti-C-Myc-DDK
• ACCN: NM_001184
• ORF Size: 7926 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC224837).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001184.2
• RefSeq Size: 8265 bp
• RefSeq ORF: 7935 bp
• Locus ID: 545
• UniProt ID: Q13535
• Cytogenetics: 3q23
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Cell cycle, p53 signaling pathway
• MW: 301.2 kDa
• Gene Summary: The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]