PFKFB1 (NM_002625) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC224599L1V

Lenti ORF particles, PFKFB1 (Myc-DDK tagged) - Human 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (PFKFB1), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: PFKFB1
• Synonyms: F6PK; HL2K; PFRX
• Mammalian Cell Selection: None
• Vector: pLenti-C-Myc-DDK
• ACCN: NM_002625
• ORF Size: 1413 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC224599).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_002625.1
• RefSeq Size: 1756 bp
• RefSeq ORF: 1416 bp
• Locus ID: 5207
• UniProt ID: P16118
• Cytogenetics: Xp11.21
• Protein Families: Druggable Genome
• Protein Pathways: Fructose and mannose metabolism
• MW: 54.7 kDa
• Gene Summary: This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]