SETD7 (NM_030648) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC219244L2V

Lenti ORF particles, SETD7 (mGFP-tagged) - Human SET domain containing (lysine methyltransferase) 7 (SETD7), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: SETD7
• Synonyms: KMT7; SET7; SET7/9; SET9
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_030648
• ORF Size: 1098 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC219244).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_030648.2
• RefSeq Size: 7012 bp
• RefSeq ORF: 1101 bp
• Locus ID: 80854
• UniProt ID: Q8WTS6
• Cytogenetics: 4q31.1
• Domains: SET, MORN
• Protein Families: Druggable Genome
• Protein Pathways: Lysine degradation
• MW: 40.5 kDa
• Gene Summary: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.[UniProtKB/Swiss-Prot Function]