JAML (NM_001098526) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC218818L2V

Lenti ORF particles, AMICA1 (mGFP-tagged) - Human adhesion molecule, interacts with CXADR antigen 1 (AMICA1), transcript variant 1, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: JAML
• Synonyms: AMICA; AMICA1; CREA7-1; CREA7-4; Gm638
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_001098526
• ORF Size: 1182 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC218818).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001098526.1
• RefSeq Size: 1957 bp
• RefSeq ORF: 1185 bp
• Locus ID: 120425
• UniProt ID: Q86YT9
• Cytogenetics: 11q23.3
• Protein Families: Transmembrane
• MW: 44.2 kDa
• Gene Summary: Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.[UniProtKB/Swiss-Prot Function]