PRODH2 (NM_021232) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC215144L2V

Lenti ORF particles, PRODH2 (mGFP-tagged) - Human proline dehydrogenase (oxidase) 2 (PRODH2), 200ul, >10^7 TU/mL

Product Images

RC215144L2 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC215144L2V particle to overexpress human PRODH2-mGFP fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: PRODH2
• Synonyms: HSPOX1; HYPDH
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_021232
• ORF Size: 1608 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC215144).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_021232.1, NP_067055.1
• RefSeq Size: 1677 bp
• RefSeq ORF: 1383 bp
• Locus ID: 58510
• UniProt ID: Q9UF12
• Cytogenetics: 19q13.12
• Protein Pathways: Arginine and proline metabolism, Metabolic pathways
• MW: 58.7 kDa
• Gene Summary: The protein encoded by this gene catalyzes the first step in the catabolism of trans-4-hydroxy-L-proline, an amino acid derivative obtained through food intake and collagen turnover. One of the downstream products of this catabolism is glyoxylate, which in people with disorders of glyoxalate metabolism can lead to an increase in oxalate levels and the formation of calcium-oxalate kidney stones. Therefore, this gene may serve as a therapeutic target against primary hyperoxalurias (PH). This gene is similar to proline dehydrogenase (oxidase) 1, a mitochondrial enzyme that catalyzes the first step in proline catabolism. [provided by RefSeq, Jan 2017]