Fibulin 5 (FBLN5) (NM_006329) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC204683L2V

Lenti ORF particles, FBLN5 (mGFP-tagged) - Human fibulin 5 (FBLN5), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: Fibulin 5
• Synonyms: ADCL2; ARCL1A; ARMD3; DANCE; EVEC; FIBL-5; HNARMD; UP50
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_006329
• ORF Size: 1344 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC204683).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_006329.2, NP_006320.2
• RefSeq Size: 2637 bp
• RefSeq ORF: 1347 bp
• Locus ID: 10516
• UniProt ID: Q9UBX5
• Cytogenetics: 14q32.12
• Domains: EGF_CA, EGF, EGF
• Protein Families: Secreted Protein
• MW: 50.2 kDa
• Gene Summary: The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]