ITGB3BP (NM_014288) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC200064L2V

Lenti ORF particles, ITGB3BP (mGFP-tagged) - Human integrin beta 3 binding protein (beta3-endonexin) (ITGB3BP), transcript variant 2, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: ITGB3BP
• Synonyms: CENP-R; CENPR; HSU37139; NRIF3; TAP20
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_014288
• ORF Size: 531 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC200064).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_014288.3
• RefSeq Size: 1019 bp
• RefSeq ORF: 534 bp
• Locus ID: 23421
• UniProt ID: Q13352
• Cytogenetics: 1p31.3
• Protein Families: Druggable Genome, Stem cell - Pluripotency, Transcription Factors
• MW: 20.2 kDa
• Gene Summary: This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]