SOCS1 Rabbit Polyclonal Antibody

CAT#: TA890038S

Rabbit polyclonal anti-SOCS1 Antibody

Product Images

HEK293T cells were transfected with the pCMV6-ENTRY control (Cat# PS100001, Left lane) or pCMV6-ENTRY SOCS1 (Cat# RC220847, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SOCS1 antibody (Cat# TA890038). Positive lysates LY401230 (100ug) and LC401230 (20ug) can be purchased separately from OriGene.

• 

  Western blot analysis of extracts (35ug) from different cell lines or tissues by using anti-SOCS1 rabbit polyclonal antibody (TA890038).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500~1:1000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human SOCS1
• Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: 0.97mg/ml
• Purification: Purified from the immunized serum by affinity chromatography (Protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 23.4 kDa
• Gene Name: suppressor of cytokine signaling 1
• Database Link:
  NP_003736
  Entrez Gene 12703 MouseEntrez Gene 252971 RatEntrez Gene 8651 Human
  UniProt ID O15524
• Background: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]
• Synonyms: CIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP3

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency, Stem cell relevant signaling - JAK/STAT signaling pathway
• Protein Pathways: Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus, Ubiquitin mediated proteolysis