HNF1 beta (HNF1B) Rabbit Polyclonal Antibody
Rabbit polyclonal HNF1B Antibody
Product Datasheet for 'TA890005'
|Recommend Dilution||WB 1:500, IHC 1:150|
|Immunogen||Synthetic peptide conjugated to KLH derived from within residues 50-150 of Human HNF1B.|
|Formulation||PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Predicted Protein Size||61.1 kDa|
|Gene Name||HNF1 homeobox B|
|Background||This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]|
|Synonyms||FJHN; HNF-1-beta; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3; LFB3; MODY5; TCF-2; TCF2; VHNF1|
|Protein Families||Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Transcription Factors|
|Protein Pathways||Maturity onset diabetes of the young|
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