Angiopoietin 1 (ANGPT1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI8H2]

CAT#: TA804679AM

ANGPT1 mouse monoclonal antibody, clone OTI8H2 (formerly 8H2), Biotinylated

Product Images

Human recombinant protein fragment corresponding to amino acids 198-498 of human ANGPT1 (NP_001137) produced in E.coli.

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  Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-ANGPT1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris, pH8.5, 120°C for 3min, TA804679)

Specifications

Product Data

• Clone Name: OTI8H2
• Applications: IHC, WB
• Recommended Dilution: WB 1:2000, IHC 1:150
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human recombinant protein fragment corresponding to amino acids 198-498 of human ANGPT1 (NP_001137) produced in E.coli.
• Formulation: PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 0.5 mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Biotin
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 57.3 kDa
• Gene Name: angiopoietin 1
• Database Link:
  NP_001137
  Entrez Gene 11600 MouseEntrez Gene 89807 RatEntrez Gene 284 Human
  UniProt ID Q15389
• Background: Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]
• Synonyms: AGP1; AGPT; ANG1; HAE5

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein