VEGFA Mouse Monoclonal Antibody [Clone ID: OTI2B9]
VEGFA mouse monoclonal antibody, clone OTI2B9 (formerly 2B9)
Product Datasheet for 'TA802346'
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|Recommend Dilution||WB 1:500,|
|Immunogen||Human recombinant protein fragment corresponding to amino acids 206-412 of human VEGFA (NP_001020537) produced in E.coli.|
|Formulation||PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purification||Purified from mouse ascites fluids by affinity chromatography|
|Predicted Protein Size||45.3 kDa|
|Gene Name||vascular endothelial growth factor A|
|Background||This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008].|
|Protein Families||Secreted Protein, Druggable Genome|
|Protein Pathways||Cytokine-cytokine receptor interaction, mTOR signaling pathway, VEGF signaling pathway, Focal adhesion, Pathways in cancer, Renal cell carcinoma, Pancreatic cancer, Bladder cancer|