BNP (NPPB) Rabbit Monoclonal Capture Antibody [Clone ID: OTIR5G8]

CAT#: TA600562

BNP Capture Rabbit Monoclonal antibody,clone OTIR5G8

Product Images

BNP ELISA with 5G8 Capture (TA600562) and 5D11 Detection (TA700562) Antibodies. Substrate used: Synthetic peptide with disulfide bond

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  BNP Luminex ELISA with 5G8 Capture (TA600562) and 5D11 Detection (TA700562) Antibodies. Substrate used: BNP plasma

Specifications

Product Data

• Clone Name: OTIR5G8
• Applications: ELISA, LMNX
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human BNP. The exact sequence is proprietary.
• Formulation: PBS (pH7.3) containing 0.05% sodium azide
• Concentration: 0.5 mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C.
  Avoid repeat freeze/thaw cycles.
• Predicted Protein Size: 14.7 kDa
• Gene Name: natriuretic peptide B
• Database Link:
  NP_002512
  Entrez Gene 4879 Human
  UniProt ID P16860
• Background: This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020]
• Synonyms: BNP; Iso-ANP

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Stem cell - Pluripotency