AMH Rabbit Monoclonal Antibody [Clone ID: OTIR5C11]

CAT#: TA592068

AMH Rabbit monoclonal antibody, clone OTIR5C11

Specifications

Product Data

• Clone Name: OTIR1A3 OTIR1B8 OTIR1E3 OTIR1F8 OTIR2G3 OTIR2G3B5 OTIR2H6 OTIR3B3 OTIR3G5 OTIR4F7 OTIR4G8 OTIR5B9 OTIR5C11 OTIR5C9 OTIR5D9
• Applications: ELISA
• Recommended Dilution: ELISA 1:5000-10000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Recombinant protein (26-560aa) of human AMH produced in HEK306
• Formulation: PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Predicted Protein Size: 59.17 kDa
• Gene Name: anti-Mullerian hormone
• Database Link:
  NP_000470
  Entrez Gene 268 Human
  UniProt ID P03971
• Background: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2016]
• Synonyms: MIF; MIS

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, TGF-beta signaling pathway