NCR1 Human Monoclonal Antibody [Clone ID: Bab281]

CAT#: TA399809

Anti-NKp46 [Bab281], Human IgG1, kappa

Specifications

Product Data

• Clone Name: Bab281
• Applications: FC, IF, IP
• Reactivities: Human, Macaque
• Modifications: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
• Host: Human
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Immunogen: The original antibody was generated by immunizing Balb/c mice with recombinant human NKp46 protein.
• Specificity: The antibody is specific for human NKp46. The antibody cross-reacts with macaque NK46 but does not cross-react with mouse NKp46. NKp46 is a receptor expressed by NK cells.
  
  The antibody was used to immunoprecipitate NKp46 molecules from NK and COS-7 cells (Pessino et al., 1998; PMID 9730896 and Cantoni et al. 1999; PMID: 10049942). NK cells were analyzed for NKp46 surface expression by immunofluorescence and Flow Cytometry analysis using the antibody (Sivori et al., 1999; PMID: 10359120). The antibody binding to NKp46 promoted an increase of cytolytic activity in NK cells (Sivori et al., 1997; PMID: 9314561 and Sivori et al., 1999; PMID: 10359120).
• Formulation: PBS with 0.02% Proclin 300.
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
• Database Link:
  UniProt ID O76036
• Synonyms: CD335; hNKp46; Lymphocyte antigen 94 homolog; Natural cytotoxicity triggering receptor 1; Natural killer cell p46-related protein; NK-p46; NK cell-activating receptor