BIRC5 Rabbit Polyclonal Antibody

CAT#: TA392516

Survivin(Ab-117) polyclonal antibody

Product Images

Immunofluorescence analysis of Jurkat cells using Survivin antibody at dilution of 1:50.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1:2000~1:5000 IF: 1:50~1:200
• Reactivities: Human, Rat, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to Human Survivin.
• Specificity: Survivin(Ab-117) polyclonal antibody detects endogenous levels of Survivin protein.
• Formulation: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Predicted Protein Size: ~ 18 kDa
• Gene Name: baculoviral IAP repeat containing 5
• Database Link:
  Entrez Gene 332 Human
  UniProt ID O15392
• Background: Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy. Survivin binds and inhibits caspase-3, controlling the checkpoint in the G2/M-phase of the cell cycle by inhibiting apoptosis and promoting cell division. This regulatory process requires the phosphorylation of survivin at Thr34 by p34 cdc2 kinase. Gene targeting using a Thr34 phosphorylation-defective survivin mutant, as well as antisense survivin, have been shown to inhibit tumor growth.
• Synonyms: API4; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; Baculoviral IAP repeat-containing protein 5; BIRC5; IAP4
• Note: For research use only, not for use in diagnostic procedure.