TRIF (TICAM1) Rabbit Monoclonal Antibody [Clone ID: R02-2A9]

CAT#: TA385408

TRIF Rabbit monoclonal Antibody

Product Images

Western blot analysis of TRIF in rat testis lysates using TRIF antibody.

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  Western blot analysis of TRIF in K562, 3T3, Hela lysates using TRIF antibody.

Specifications

Product Data

• Clone Name: R02-2A9
• Applications: IP, WB
• Recommended Dilution: WB: 1/1000
  IP: 1/20
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Recombinant protein of human TRIF
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 76 kDa; Observed MW: 98 kDa
• Gene Name: toll like receptor adaptor molecule 1
• Database Link:
  Entrez Gene 148022 Human
  UniProt ID Q8IUC6
• Background: Swiss-Prot Acc.Q8IUC6.Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines .
• Synonyms: MGC35334; PRVTIRB; TICAM-1; TRIF