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SMAD2 Rabbit Monoclonal Antibody [Clone ID: R03-3F8]
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Specifications
| Product Data | |
| Clone Name | R03-3F8 |
| Applications | IF, IHC, IP, WB |
| Recommended Dilution | WB: 1/1000-1/5000 IHC: 1/20 ICC/IF: 1/20-1/100 IP: 1/20 |
| Reactivities | Human, Rat, Hamster |
| Host | Rabbit |
| Isotype | IgG |
| Clonality | Monoclonal |
| Immunogen | A synthetic peptide of human Smad2 |
| Formulation | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Concentration | lot specific |
| Purification | Affinity Purified |
| Conjugation | Unconjugated |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Stability | 1 year |
| Predicted Protein Size | Calculated MW: 52 kDa; Observed MW: 52 kDa |
| Gene Name | SMAD family member 2 |
| Database Link | |
| Background | Swiss-Prot Acc.Q15796.Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. |
| Synonyms | hMAD-2; hSMAD2; JV18; JV18-1; MADH2; MADR2; MGC22139; MGC34440 |
| Reference Data | |
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