HEXIM1 Rabbit Polyclonal Antibody

CAT#: TA384406

HEXIM1 Rabbit polyclonal Antibody

Product Images

Western blot analysis of HEXIM1 in rat HEART lysates using HEXIM1 antibody.

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  Western blot analysis of HEXIM1 in NIH/3T3 lysates using HEXIM1 antibody. The lane on the right is blocked with the synthesized peptide.

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  Western blot analysis of HEXIM1 in theHeLa lysates using HEXIM1 antibody

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  Immunofluorescence analysis of HEXIM1 in HeLa using HEXIM1 antibody. The picture on the right is blocked using the synthesized peptide.

Specifications

Product Data

• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: WB: 1/500-1/2000
  IHC: 1/100-1/300
  IF: 1/200-1/1000
  ELISA: 1/10000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The antiserum was produced against synthesized peptide derived from human HEXIM1. AA range:181-230
• Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Observed MW (kDa):40
• Gene Name: hexamethylene bis-acetamide inducible 1
• Database Link:
  Entrez Gene 10614 Human
  UniProt ID O94992
• Background: Swiss-Prot Acc.O94992.Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).
• Synonyms: CLP-1; CLP1; EDG1; FLJ13562; HIS1; HMBA-inducible; MAQ1