WDFY2 Rabbit Polyclonal Antibody

CAT#: TA369749

WDFY2 rabbit polyclonal antibody

Product Images

Gel: 8%SDS-PAGE Lysate: 40 μg Lane: Mouse kidney tissue lysate Primary antibody: TA369749 (WDFY2 Antibody) at dilution 1/350 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 15 seconds

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  Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using TA369749 (WDFY2 Antibody) at dilution 1/40 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using TA369749 (WDFY2 Antibody) at dilution 1/40, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Mouse kidney tissue lysate
  IHC: 30-150
  Positive control: Human cervical cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human WDFY2
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C.
• Stability: 1 year
• Predicted Protein Size: 45 kDa
• Gene Name: WD repeat and FYVE domain containing 2
• Database Link:
  Entrez Gene 115825 Human
  UniProt ID Q96P53
• Background: WD repeat and FYVE domain-containing protein 2 (WDFY2), also known as WDF2 and ZFYVE22, is a 400 amino acid protein that localizes to a set of small endosomes that are found within 100 nm from the plasma membrane. Highly conserved between species, WDFY2 consists of one FYVE-type zinc finger and seven WD repeats. The FYVE domain is a cysteine-rich domain of about 70 amino acids. Its primary role is to target signal-transducing proteins to cell membranes through binding to the membrane lipid phosphatidylinositol-3-phosphate with high specificity. WD-repeats are generally found in clusters of seven. They have no intrinsic catalytic activity, but they serve as a platform for protein-protein interactions. WDFY2 is suspected to play a critical role in the endocytic pathway.
• Synonyms: PROF; RP11-147H23.1; WDF2; ZFYVE22