FBXW8 Rabbit Polyclonal Antibody

CAT#: TA368316

FBXW8 rabbit polyclonal antibody

Product Images

Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA368316 (FBXW8 Antibody) at dilution 1/65 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA368316 (FBXW8 Antibody) at dilution 1/65, treated with synthetic peptide. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TA368316 (FBXW8 Antibody) at dilution 1/65 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TA368316 (FBXW8 Antibody) at dilution 1/65, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-300
  Positive control: Human esophagus cancer
  Predicted cell location: Cytoplasm or Nucleus
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human FBXW8
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C.
• Stability: 1 year
• Gene Name: F-box and WD repeat domain containing 8
• Database Link:
  Entrez Gene 26259 Human
  UniProt ID Q8N3Y1
• Background: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
• Synonyms: FBW6; FBW8; FBX29; FBXO29; FBXW6; MGC33534