EVI1 (MECOM) Rabbit Polyclonal Antibody

CAT#: TA368275S

MECOM rabbit polyclonal antibody

Product Images

Gel: 6%SDS-PAGE Lysate: 40 μg Lane: NIH/3T3 cell lysate Primary antibody: TA368275 (MECOM Antibody) at dilution 1/400 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 4 minutes

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  Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using TA368275 (MECOM Antibody) at dilution 1/40 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using TA368275 (MECOM Antibody) at dilution 1/40, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: NIH/3T3 cell lysate
  IHC: 30-150
  Positive control: Human ovarian cancer
  Predicted cell location: Nucleus
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human MECOM
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C.
• Stability: 1 year
• Predicted Protein Size: 118 kDa
• Gene Name: MDS1 and EVI1 complex locus
• Database Link:
  Entrez Gene 2122 Human
  UniProt ID Q03112
• Background: The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.
• Synonyms: D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1; Mds1-Evi1; Prdm3; Znfpr1b1