ADAMTS8 Rabbit Polyclonal Antibody

CAT#: TA367532

ADAMTS8 rabbit polyclonal antibody

Product Images

Immunohistochemistry of paraffin-embedded Human liver cancer using TA367532 (ADAMTS8 Antibody) at dilution 1/120 (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human liver cancer using TA367532 (ADAMTS8 Antibody) at dilution 1/120, treated with synthetic peptide. (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human gastric cancer using TA367532 (ADAMTS8 Antibody) at dilution 1/120 (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human gastric cancer using TA367532 (ADAMTS8 Antibody) at dilution 1/120, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 100-300
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human ADAMTS8
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C.
• Stability: 1 year
• Gene Name: ADAM metallopeptidase with thrombospondin type 1 motif 8
• Database Link:
  Entrez Gene 11095 Human
  UniProt ID Q9UP79
• Background: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor.
• Synonyms: ADAM-TS8; ADAMTS-8; FLJ41712; METH-2; METH-8; METH2