Casp3 Rabbit Polyclonal Antibody

CAT#: TA357784

Casp3 Antibody - middle region

Product Images

Host: Rabbit Target Name: Casp3 Sample Type: Mouse Liver lysates Antibody Dilution: 1.0ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Mouse Casp3
• Specificity: Expected reactivity: Cow, Dog, Goat, Guinea Pig, Horse, Human, Pig, Rat, Sheep
  Homology: Cow: 100%; Dog: 93%; Goat: 93%; Guinea Pig: 85%; Horse: 92%; Human: 86%; Pig: 93%; Rat: 92%; Sheep: 93%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 31kDa
• Gene Name: caspase 3
• Database Link:
  NP_033940
  Entrez Gene 12367 Mouse
  UniProt ID P70677
• Background: Casp3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond, cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain, cleaves and activates caspase-6, -7 and -9, triggers cell adhesion in sympathetic neurons through RET cleavage, cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.
• Synonyms: apopain; CASP-3; CPP-32; CPP32; CPP32B; procaspase3; SCA-1; Yama