Caspase 5 (CASP5) Rabbit Polyclonal Antibody

CAT#: TA357505

CASP5 Antibody - middle region

Product Images

WB Suggested Anti-CASP5 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: A549 cell lysate

Specifications

Product Data

• Applications: FC, WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CASP5
• Specificity: Expected reactivity: Cow, Guinea Pig, Human
  Homology: Cow: 83%; Guinea Pig: 82%; Human: 100%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 43kDa
• Gene Name: caspase 5
• Database Link:
  NP_001129581
  Entrez Gene 838 Human
  UniProt ID P51878
• Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.
• Synonyms: CASP-5; ICE(rel)-III; ICE(rel)III; ICEREL-III; ICH-3; ICH3; MGC141966

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: NOD-like receptor signaling pathway