Wilms Tumor Protein (WT1) Mouse Monoclonal Antibody [Clone ID: WT49]

CAT#: TA355362

Wilms' Tumor Mouse Monoclonal Antibody

Product Images

Human kidney: immunohistochemical staining for Wilms' tumor. Note the nuclear staining of invasive tumor cells. Wilms' Tumor: clone WT49

Specifications

Product Data

• Clone Name: WT49
• Applications: IHC
• Recommended Dilution: 1:100
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: A prokaryotic recombinant protein containing 1–181 amino acids of the N-terminal of the Wilms’ Tumor protein
• Specificity: Human Wilms’ Tumor WT1 gene product
• Formulation: Liquid tissue culture supernatant containing sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: Wilms tumor 1
• Database Link:
  Entrez Gene 7490 Human
  UniProt ID P19544
• Background: Wilms' tumor protein (WT1) has a role in transcriptional regulation and is expressed in the kidney and a subset of hematopoietic cells. Alteration of transcription factor function is a common mechanism in oncogenesis. The WT1 protein contains a DNA binding domain and any deletions or point mutations of the WT1 gene which destroy this activity result in the development of the childhood nephroblastoma Wilms' tumor and Denys-Drash syndrome. The description of WT1 involvement in nephroblastoma is not clear.
• Synonyms: AWT1; GUD; OTTHUMP00000037553; WAGR; WIT-2; WT33