MUM1 (IRF4) Mouse Monoclonal Antibody [Clone ID: EAU32]

CAT#: TA355319

Multiple Myeloma Oncogene 1 (MUM-1) Mouse Monoclonal Antibody

Product Images

Human tonsil: immunohistochemical staining for MUM-1. Multiple Myeloma Oncogene 1: clone EAU32

Specifications

Product Data

• Clone Name: EAU32
• Applications: IHC
• Recommended Dilution: 1:100
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Prokaryotic recombinant protein corresponding to 313 amino acids of the human multiple myeloma oncogene 1 (MUM-1) molecule
• Specificity: Human multiple myeloma oncogene 1 (MUM-1)
• Formulation: Liquid tissue culture supernatant containing sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: interferon regulatory factor 4
• Database Link:
  Entrez Gene 3662 Human
  UniProt ID Q15306
• Background: The MUM-1 (multiple myeloma oncogene 1) gene was originally identified because of its involvement in the t(6:14) translocation observed in multiple myeloma, which causes the juxtaposition of the MUM-1 gene to the Ig heavy chain locus. MUM-1 is expressed in late plasma cell directed stages of B cell differentiation and in activated T cells, suggesting that MUM-1 may serve as a marker for lympho-hemopoietic neoplasms derived from these cells. The morphologic spectrum of MUM-1 expressing cells has been found to range from that of a centrocyte to that of a plasmablast/plasma cell. Consequently the histogenic value of MUM-1 may be to provide a marker to aid in the identification of the transition from BCL-6 positive (germinal center B cells) to CD138 positive (immunoblasts and plasma cells).
• Synonyms: IRF-4; LSIRF; MUM1; NF-EM5