PLAC1 Rabbit Polyclonal Antibody

CAT#: TA354853

Rabbit anti PLAC1(pY147) Polyclonal Antibody

Product Images

WB: The cell lysate derived MCF-7 treated by 100 nM E2 (sigma) for 12 hr, followed by separation onto 12% SDS-PAGE, transferred onto NC membrane, and immunoblotted by Rabbit anti-Phosphospecific PLAC1 (pY147) at 1:500. An immunoreactive major band was observed at ~22 kDa.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to the phosphorylation site at Tyrosine 147 surrounding the epitope -EKCYEVF- of human Placenta-specific 1 protein. This sequence is derived from human origin.
• Formulation: This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: ~22 kDa
• Gene Name: placenta specific 1
• Database Link:
  NP_068568
  Entrez Gene 10761 Human
  UniProt ID Q9HBJ0
• Background: The PLAC1, a placenta-specific gene, which encodes a putative cell surface protein, is highly expressed in placenta, testis, and wide range of human malignancies, most frequently in breast cancer, and essentially involved in cancer cells proliferation, migration and invasion. The activation of PLAC1 is selectively controlled by ubiquitous transcription factor SP1 and positively correlated between PLAC1 and ER-alpha in breast cancer. PLAC1 is also expressed in human hepatocellular cancer tissues as well as in several other types of cancer tissues and/or tumor cell lines. PLAC1 represents a new class of tumor associated antigen with restricted expression in placenta and cancer tissues, that may serve as a target for cancer vaccination.
• Synonyms: CT92; OOSP2L

Reference Data

• Protein Families: Secreted Protein