SOCS1 Rabbit Polyclonal Antibody

CAT#: TA354506

Rabbit anti SOCS1 Polyclonal Antibody

Product Images

WB: The tissue /cell lysate derived from mouse liver (lane 2), mouse muscle (Lane 3) and MCF-7 (Lane 4) were immunoprobed by Rabbit anti-SCOS-1 at 1:500. An immunoreactive band is observed around ~24kDa.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to C-terminus of SOCS-1 protein from human and mouse origins.
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 4
• Gene Name: suppressor of cytokine signaling 1
• Database Link:
  NP_003736
  Entrez Gene 12703 MouseEntrez Gene 252971 RatEntrez Gene 8651 Human
  UniProt ID O15524
• Background: Cytokines induce a variety of biological responses by binding to specific cell surface receptors and activating cytoplasmic signal transduction pathways which are suppressed by other transcriptional factors. Proteins that mediate these signals from the cell surface to the nucleus include JAKs and STATs, while SOCS (Suppressor of cytokine signaling) proteins inhibit those signaling. The SOCS family comprises at least 8 members, SOCS1 to SOCS7 and CIS (cytokine inducible SH2 containing protein). Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C terminal motif named the SOCS box. SOCS 1 inhibition of signal transduction appears to occur by binding to and inhibiting the catalytic activity of members of JAK family of cytoplasmic kinases (direct JAK2 kinase inhibition). SOCS1 is an important negative regulator of JAK-STAT signal pathway.
• Synonyms: CIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP3

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency, Stem cell relevant signaling - JAK/STAT signaling pathway
• Protein Pathways: Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus, Ubiquitin mediated proteolysis